Comparison of the Effects of Soy Protein and Whey Protein Supplementation during Exercise: a Systematic Review


  • Suelen Maiara Medeiros da Silva Universidade Federal da Grande Dourados, Programa de Pos-Graduação Stricto Sensu em Ciências Saúde. MS, Brasil.
  • Bárbara Cristovão Carminati Universidade Federal da Grande Dourados, Programa de Pos-Graduação Stricto Sensu em Ciências Saúde. MS, Brasil.
  • Valfredo de Almeida Santos Junior Universidade de Campinas, Programa de Pos-Graduação Stricto Sensu em Alimentos e Nutrição. SP, Brasil.
  • Pablo Christiano Barboza Lollo Universidade de Campinas, Faculdade de Engenharia de Alimentos. SP, Brasil.




The interest of the supplementation market for the soy protein consumption  to optimize physical and metabolic performance after exercise is increasing. However, evidence suggests that the  soy protein ingestion has lower anabolic properties when compared with whey protein. The purpose of this systematic review was to compare the effects of whey protein and soy protein supplementation on the  muscle functions maintenance after exercise. This review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Articles were searched for in the Pubmed database and included studies comparing the effects of soy protein and whey protein consumption on protein synthesis, lean mass gain and oxidative stress reduction in response to endurance or resistance training. Thirteen trials were included in this review. The results showed that the whey protein consumption is superior to that of soy protein with respect to protein synthesis and lean mass gain, but soy protein showed superior results in reducing oxidative stress. Future research comparing both soy and whey protein are needed to define protein source to be used in nutritional interventions to protein synthesis, lean mass gain and oxidative stress in different populations.


Keywords: Soybean Proteins. Milk Proteins. Protein Biosynthesis. Hypertrophy.



O interesse do mercado de suplementação pelo consumo de proteína de soja para otimizar o desempenho físico e metabólico após o exercício está aumentando. No entanto, evidências sugerem que a ingestão da proteína de soja tem propriedades anabólicas mais baixas quando comparada à proteína do soro do leite. O objetivo desta revisão sistemática foi comparar os efeitos da suplementação com whey protein e proteína de soja na manutenção das funções musculares após o exercício. Esta revisão foi realizada usando os Itens de Relatório Preferidos para Revisões Sistemáticas e Meta-Análises (PRISMA). Os artigos foram pesquisados na base de dados Pubmed e incluíram estudos comparando os efeitos da proteína de soja e do consumo de proteínas do soro na síntese protéica, ganho de massa magra e redução do estresse oxidativo em resposta ao treinamento de resistência ou resistência. Treze ensaios foram incluídos nesta revisão. Os resultados mostraram que o consumo de proteína de soro é superior ao da proteína de soja em relação à síntese protéica e ao ganho de massa magra, mas a proteína de soja apresentou resultados superiores na redução do estresse oxidativo. Pesquisas futuras comparando a soja e a proteína do soro do leite são necessárias para definir a fonte protéica a ser usada em intervenções nutricionais para a síntese protéica, ganho de massa magra e estresse oxidativo em diferentes populações.


Palavras-chave: Proteínas de Soja. Proteínas do Leite. Biossíntese de Proteínas. Hipertrofia.


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